History

Professor Bruno Walther at Lund University, one of Sweden’s most experienced surgeons in the field of cancer in the esophagus and stomach, had after over 15,000 endoscopic examinations with biopsies (organ tissue tests) realized the difficulty with sampling deep and difficultly situated tumors. In these cases it was hard to provide an early and reliable diagnosis often resulting in using more complicated methods, including surgery, to diagnose the patient. It was obvious to Professor Walther and many of his colleagues that available instruments did not fulfill the need for early and reliable diagnoses via routine endoscopic examination. This resulted in longer time to reach diagnoses and exposing the patient to further and more complicated tests.

Why not use a drilling motion
to access deep tumor tissue?

However, it was not Professor Walther, but his son Dr Charles Walther who came up with a possible solution to the problem. Dr Charles Walther is a cancer researcher at Lund University and a senior consultant in clinical pathology at Lund University Hospital. He continuously saw insufficient tumor biopsies in the microscope as a result of the difficult sampling of certain types of tumors. After several years of work on the problem of insufficient samples, both from a clinical and research perspective, Charles had the idea for a drilling motion to reach the tumor cells. The idea for the instrument, EndoDrill®, was then envisioned during one of his runs. After a few years of work, in 2012 Charles patented the idea and the instrument won TVs-show “The Inventors” that was broadcast on Swedish national television TV4. The following year the company BiBBInstruments (name inspired by his mother) was formed in 2013.

BiBBInstruments has since then developed and clinically validated the EndoDrill® GI Upper biopsy instrument, whose function results in better samples from deep tumors and deep tissue below the stomach surface. The instrument was launched on the Swedish market in August 2017 and is the first instrument in a planned product family, EndoDrill®.

 

Historic milestones

Year Milestone
2012
  • Charles Walther’s idea for a new biopsy instrument with a drilling-motion is finalized
  • The first patent application is submitted for EndoDrill®
  • Winner of TV4’s “The Inventors”
2013
  • BiBBInstruments AB is founded
  • Awarded a grant of SEK 2 million from Vinnova
2014
  • CE-marking of reusable instruments
  • Production of reusable instruments from ISO-certified manufacturers
  • Start of a randomized clinical study at Skåne University Hospital in Lund
  • PwC’s Innovation Award 2014 (Silver)
  • Submission of second patent family
2015
  • Contribution of SEK 2.2 million from the Kamprad Family Foundation
  • Randomized clinical trial comprising ten patients concluded (Proof of Concept)
  • Positive FTO Analysis (Freedom To Operate, limited analysis)
  • Registration of the EndoDrill® trademark in Sweden
2016
  • The company is awarded SuperStartup of the year-2016 by Veckans Affärer/ALMI
  • Randomized clinical study published in Surgical Innovation
  • Patent approved in China
  • Audit for ISO 13485 certificate performed by notified body
  • Fredrik Lindblad takes over as CEO
  • First purchase order for the EndoDrill® GI Upper in Sweden
  • The first series of commercial sterile disposable instruments manufactured
2017
  • The company receives SEK 4.6 million through a directed new share issue
  • EndoDrill® GI Upper used in +60 patients
  • Three ongoing academic studies with EndoDrill® GI Upper
  • The disposable instrument EndoDrill® GI Upper is CE-marked
  • BiBB’s Quality Management System is certified according to EN ISO 13485: 2012.
  • Training of 15 hospitals in Sweden and several verified customer orders
  • First deliveries of EndoDrill® GI Upper in Sweden
  • The company is listed on AktieTorget
  • Secures SEK 13 million in a heavily oversubscribed public offer
  • First patent family approved in Europe